The only way to really resolve this situation is to combine 5a and 6a, so that way you can have a 16-man regional bracket instead of an 8-man bracket.
Personally, I think this should be done when you look at how many kids have losing records in 5a and 6a. A combined 48 kids going to state this year have losing records in 5-6A, compared to a combined 13 in 321-4a. Something just doesn't seem fair here.